|Application ||WB, E|
|Calculated MW||24145 Da|
|Other Names||Metalloproteinase inhibitor 3, Protein MIG-5, Tissue inhibitor of metalloproteinases 3, TIMP-3, TIMP3|
|Target/Specificity||This TIMP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 176-210 amino acids from the C-terminal region of human TIMP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMP3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Uria J.A.,et al.Cancer Res. 54:2091-2094(1994).
Wilde C.G.,et al.DNA Cell Biol. 13:711-718(1994).
Silbiger S.M.,et al.Gene 141:293-297(1994).
Wick M.,et al.J. Biol. Chem. 269:18953-18960(1994).
Stoehr H.,et al.Genome Res. 5:483-487(1995).
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