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SAG Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SAG Antibody (C-Term) AP21724b
    Anti-SAG Antibody (C-Term) at 1:2000 dilution + mouse eyeball lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 45 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P10523
Reactivity Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 45120 Da
Antigen Region 273-307 aa
Additional Information
Gene ID 6295
Other Names S-arrestin, 48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin, SAG
Target/Specificity This SAG antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-307 amino acids from the human SAG.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSAG Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SAG
Function Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049).
Cellular Location Cell projection, cilium, photoreceptor outer segment. Membrane {ECO:0000250|UniProtKB:P20443}; Peripheral membrane protein {ECO:0000250|UniProtKB:P20443}. Note=Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity) Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866) {ECO:0000250|UniProtKB:P08168, ECO:0000269|PubMed:3720866}
Tissue Location Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level)
Research Areas
Citations (0)
citation

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Background

Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.

References

Yamaki K.,et al.FEBS Lett. 234:39-43(1988).
Yamaki K.,et al.FEBS Lett. 236:507-507(1988).
Yamamoto S.,et al.Nat. Genet. 15:175-178(1997).
Hillier L.W.,et al.Nature 434:724-731(2005).
Roni V.,et al.BMC Genomics 8:42-42(2007).

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$ 182.50
$ 70.00
Cat# AP21724b
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