XPNPEP2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O43895 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 75625 Da |
Gene ID | 7512 |
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Other Names | Xaa-Pro aminopeptidase 2, Aminoacylproline aminopeptidase, Membrane-bound aminopeptidase P, Membrane-bound APP, Membrane-bound AmP, mAmP, X-Pro aminopeptidase 2, XPNPEP2 |
Target/Specificity | This XPNPEP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 373-407 amino acids from the Central region of human XPNPEP2. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | XPNPEP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | XPNPEP2 |
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Function | Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q95333}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q95333} |
Tissue Location | Expressed in kidney, lung, heart, placenta, liver, small intestine and colon. No expression in brain, skeletal muscle, pancreas, spleen, thymus, prostate, testis and ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.
References
Venema R.C.,et al.Biochim. Biophys. Acta 1354:45-48(1997).
Sprinkle T.J.C.,et al.Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
Ryan J.W.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Duan Q.L.,et al.Am. J. Hum. Genet. 77:617-626(2005).
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