|Application ||WB, E|
|Calculated MW||140283 Da|
|Other Names||Ataxin-2, Spinocerebellar ataxia type 2 protein, Trinucleotide repeat-containing gene 13 protein, ATXN2, ATX2, SCA2, TNRC13|
|Target/Specificity||This ATXN2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 321-355 amino acids from human ATXN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATXN2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATX2, SCA2, TNRC13|
|Function||Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.|
|Tissue Location||Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus|
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Provided below are standard protocols that you may find useful for product applications.
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane.
Pulst S.-M.,et al.Nat. Genet. 14:269-276(1996).
Sanpei K.,et al.Nat. Genet. 14:277-284(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Imbert G.,et al.Nat. Genet. 14:285-291(1996).
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