|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||57019 Da|
|Other Names||Neuronal acetylcholine receptor subunit beta-2, CHRNB2|
|Target/Specificity||This CHRNB2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 66-100 amino acids from human CHRNB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRNB2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions.
Anand R.,et al.Nucleic Acids Res. 18:4272-4272(1990).
Elliott K.J.,et al.J. Mol. Neurosci. 7:217-228(1996).
Groot Kormelink P.J.,et al.FEBS Lett. 400:309-314(1997).
Rempel N.,et al.Hum. Genet. 103:645-653(1998).
Lueders K.K.,et al.Mamm. Genome 10:900-905(1999).
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