|Application ||WB, E|
|Calculated MW||46555 Da|
|Other Names||Bone morphogenetic protein 4, BMP-4, Bone morphogenetic protein 2B, BMP-2B, BMP4, BMP2B, DVR4|
|Target/Specificity||This BMP4 antibody is generated from a rabbit immunized with a recombinant protein of human BMP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMP4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines|
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Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).
Wozney J.M.,et al.Science 242:1528-1534(1988).
Shore E.M.,et al.Calcif. Tissue Int. 63:221-229(1998).
Oida S.,et al.DNA Seq. 5:273-275(1995).
Yanagita M.,et al.Biochem. Biophys. Res. Commun. 316:490-500(2004).
Felder B.,et al.Eur. J. Hum. Genet. 10:753-756(2002).
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