|Application ||WB, E|
|Calculated MW||226592 Da|
|Other Names||Chromodomain-helicase-DNA-binding protein 3, CHD-3, ATP-dependent helicase CHD3, Mi-2 autoantigen 240 kDa protein, Mi2-alpha, Zinc finger helicase, hZFH, CHD3|
|Target/Specificity||This CHD3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 595-629 amino acids from human CHD3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHD3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase and mitosis|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Aubry F.,et al.Eur. J. Biochem. 254:558-564(1998).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Woodage T.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:11472-11477(1997).
Ge Q.,et al.J. Clin. Invest. 96:1730-1737(1995).
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