|Application ||WB, E|
|Calculated MW||48608 Da|
|Other Names||Myc-associated zinc finger protein, MAZI, Pur-1, Purine-binding transcription factor, Serum amyloid A-activating factor-1, SAF-1, Transcription factor Zif87, ZF87, Zinc finger protein 801, MAZ, ZNF801|
|Target/Specificity||This MAZ antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 295-327 amino acids from the Central region of human MAZ.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAZ Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.|
|Cellular Location||Nucleus. Note=In brains of Alzheimer disease patients, present in a plaque- like structures|
|Tissue Location||Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).|
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May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins.
Bossone S.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:7452-7456(1992).
Pyrc J.J.,et al.Biochemistry 31:4102-4110(1992).
Tsutsui H.,et al.Biochem. Biophys. Res. Commun. 226:801-809(1996).
Parks C.L.,et al.J. Biol. Chem. 271:4417-4430(1996).
Song J.,et al.J. Biol. Chem. 273:20603-20614(1998).
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