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Ubiquilin1 (PLIC1) Antibody (C-term)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP2179c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Ubiquilin1 (PLIC1) Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | Q9UMX0 |
| Other Accession | Q99NB8, Q9NRR5, Q9QZM0, Q9UHD9, Q9JJP9, Q8R317 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 62519 Da |
Ubiquilin1 (PLIC1) Antibody (C-term) - Additional info | |
| Gene ID 29979 | |
| Other Names UBQLN1; DA41; PLIC1; Ubiquilin-1; Protein linking IAP with cytoskeleton 1 | |
| Target/Specificity This Ubiquilin1 (PLIC1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 555~584 amino acids from the center region of human PLIC1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:50~100 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Ubiquilin1 (PLIC1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Ubiquilin1 (PLIC1) Antibody (C-term) - Protein Information | |
| Name UBQLN1 | |
| Synonyms DA41, PLIC1 | |
| Function Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors (By similarity). Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation | |
| Cellular Location Cytoplasm. Nucleus. | |
| Tissue Location Ubiquitous. Highly expressed throughout the brain; detected in neurons and in neuropathological lesions, such as neurofibrillary tangles and Lewy bodies. Highly expressed in heart, placenta, pancreas, lung, liver, skeletal muscle and kidney | |
Ubiquilin1 (PLIC1) Antibody (C-term) - Related products
AP2176a: Ubiquilin1 Antibody (N-term)
AP2176c: Ubiquilin1 Antibody (Center)
AP2179a: Ubiquilin1 (PLIC1) Antibody (N-term)
AP2179c: Ubiquilin1 (PLIC1) Antibody (C-term)
RI15597: UBQLN1 predesign siRNA
BP2176a: Ubiquilin1 Antibody (N-term) Blocking Peptide
BP2176c: Ubiquilin1 Antibody (Center) Blocking Peptide
Ubiquilin1 (PLIC1) Antibody (C-term) - Application data
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The anti-PLIC1 Pab (Cat. #AP2179c) is used in Western blot to detect PLIC1 in HL-60 cell lysate.
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Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Ubiquilin1 (PLIC1) Antibody (C-term) - Research Areas
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BACKGROUND
PLIC1 is an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with Alzheimer's and Parkinson's disease.
REFERENCES
Gao, L., et al., J. Virol. 77(7):4149-4159 (2003). Kleijnen, M.F., et al., Mol. Cell 6(2):409-419 (2000). Mah, A.L., et al., J. Cell Biol. 151(4):847-862 (2000). Hanaoka, E., et al., J. Hum. Genet. 45(3):188-191 (2000).
