|Application ||WB, E|
|Calculated MW||132336 Da|
|Other Names||Regulator of G-protein signaling 3, RGP3, RGS3, RGS3|
|Target/Specificity||This RGS3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 273-307 amino acids from human RGS3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGS3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.|
|Cellular Location||Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886)|
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Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases.
Druey K.M.,et al.Nature 379:742-746(1996).
Kehrl J.H.,et al.Genomics 79:860-868(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Chatterjee T.K.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Puhl H.L. III,et al.Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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