BBC3 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q96PG8 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 26498 Da |
Antigen Region | 158-192 aa |
Gene ID | 27113 |
---|---|
Other Names | Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis, BBC3, PUMA |
Target/Specificity | This BBC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 158-192 amino acids from human BBC3. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | BBC3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | BBC3 |
---|---|
Synonyms | PUMA |
Function | [Isoform 3]: Does not affect cell growth. |
Cellular Location | Note=Contrary to isoforms 1 and 2, isoform 3 does not localize to the mitochondria |
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Provided below are standard protocols that you may find useful for product applications.
Background
Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity.
References
Nakano K.,et al.Mol. Cell 7:683-694(2001).
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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