|Application ||WB, E|
|Calculated MW||76329 Da|
|Other Names||Anoctamin-10, Transmembrane protein 16K, ANO10, TMEM16K|
|Target/Specificity||This ANO10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 620-653 amino acids from human ANO10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANO10 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.|
|Cellular Location||Cell membrane; Multi- pass membrane protein Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane|
|Tissue Location||Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.|
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Provided below are standard protocols that you may find useful for product applications.
Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Schreiber R.,et al.J. Biol. Chem. 285:7838-7845(2010).
Duran C.,et al.Acta Pharmacol. Sin. 32:685-692(2011).
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