|Application ||WB, E|
|Calculated MW||69957 Da|
|Other Names||Neuronal acetylcholine receptor subunit alpha-4, CHRNA4, NACRA4|
|Target/Specificity||This CHRNA4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 176-208 amino acids from human CHRNA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHRNA4 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor|
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Provided below are standard protocols that you may find useful for product applications.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Monteggia L.M.,et al.Gene 155:189-193(1995).
Steinlein O.K.,et al.Genomics 32:289-294(1996).
Elliott K.J.,et al.J. Mol. Neurosci. 7:217-228(1996).
Groot Kormelink P.J.,et al.FEBS Lett. 400:309-314(1997).
Deloukas P.,et al.Nature 414:865-871(2001).
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