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VLDLR Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - VLDLR Antibody (C-Term) AP21837b
    All lanes : Anti-VLDLR Antibody (C-Term) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 96 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P98155
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 96098 Da
Antigen Region 608-642 aa
Additional Information
Gene ID 7436
Other Names Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR
Target/Specificity This VLDLR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 608-642 amino acids from human VLDLR.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVLDLR Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VLDLR
Function Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE- containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein
Tissue Location Abundant in heart and skeletal muscle; also ovary and kidney; not in liver
Research Areas
Citations (0)
citation

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Background

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).

References

Gafvels M.E.,et al.Somat. Cell Mol. Genet. 19:557-569(1993).
Webb J.C.,et al.Hum. Mol. Genet. 3:531-537(1994).
Sakai J.,et al.J. Biol. Chem. 269:2173-2182(1994).
Oka K.,et al.Genomics 20:298-300(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 365.00
$ 140.00
Cat# AP21837b
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