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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   SEMA7A Antibody (C-term)   

SEMA7A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SEMA7A Antibody (C-term) AP21852b
    All lanes : Anti-SEMA7A Antibody (C-term) at 1:2000 dilution Lane 1: mouse brain lysate Lane 2: A2058 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 75 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O75326
Reactivity Human, Mouse
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 74824 Da
Additional Information
Gene ID 8482
Other Names Semaphorin-7A, CDw108, JMH blood group antigen, John-Milton-Hargen human blood group Ag, Semaphorin-K1, Sema K1, Semaphorin-L, Sema L, CD108, SEMA7A, CD108, SEMAL
Target/Specificity This SEMA7A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 521-555 amino acids from the C-terminal region of human SEMA7A.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEMA7A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEMA7A
Synonyms CD108, SEMAL
Function Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Cellular Location Cell membrane; Lipid- anchor, GPI-anchor; Extracellular side Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes
Tissue Location Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level) Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney
Research Areas
Citations (0)

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Background

Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.

References

Lange C.,et al.Genomics 51:340-350(1998).
Yamada A.,et al.J. Immunol. 162:4094-4100(1999).
Xu X.,et al.J. Biol. Chem. 273:22428-22434(1998).
Seltsam A.,et al.Transfusion 47:133-146(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 99.00
Cat# AP21852b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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