|Application ||WB, E|
|Calculated MW||243949 Da|
|Other Names||Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APC-like, APC2, APCL|
|Target/Specificity||This APC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 122-152 amino acids from human APC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APC2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.|
|Cellular Location||Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side Note=Associated with actin filaments and the microtubule network|
|Tissue Location||Widely expressed (at protein level). Specifically expressed in the CNS.|
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Provided below are standard protocols that you may find useful for product applications.
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
Nakagawa H.,et al.Cancer Res. 58:5176-5181(1998).
Nakagawa H.,et al.Jpn. J. Cancer Res. 90:982-986(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carr I.M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
van Es J.H.,et al.Curr. Biol. 9:105-108(1999).
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