|Application ||WB, E|
|Calculated MW||243949 Da|
|Other Names||Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APC-like, APC2, APCL|
|Target/Specificity||This APC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 122-152 amino acids from human APC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||APC2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.|
|Cellular Location||Cytoplasm, cytoskeleton. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side Note=Associated with actin filaments and the microtubule network|
|Tissue Location||Widely expressed (at protein level). Specifically expressed in the CNS.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.
Nakagawa H.,et al.Cancer Res. 58:5176-5181(1998).
Nakagawa H.,et al.Jpn. J. Cancer Res. 90:982-986(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carr I.M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
van Es J.H.,et al.Curr. Biol. 9:105-108(1999).
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