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APC2 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - APC2 Antibody (N-Term) AP21858a
    Anti-APC2 Antibody (N-Term) at 1:2000 dilution + Hela whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 244 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O95996
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 243949 Da
Additional Information
Gene ID 10297
Other Names Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like, APC-like, APC2, APCL
Target/Specificity This APC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 122-152 amino acids from human APC2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAPC2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name APC2
Synonyms APCL
Function Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases (PubMed:25753423). May also function in Wnt signaling by promoting the rapid degradation of CTNNB1 (PubMed:10021369, PubMed:11691822, PubMed:9823329).
Cellular Location Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Note=Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423).
Tissue Location Widely expressed (at protein level). Specifically expressed in the CNS.
Citations (0)

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Background

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.

References

Nakagawa H.,et al.Cancer Res. 58:5176-5181(1998).
Nakagawa H.,et al.Jpn. J. Cancer Res. 90:982-986(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Carr I.M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
van Es J.H.,et al.Curr. Biol. 9:105-108(1999).

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$ 295.00
$ 99.00
Cat# AP21858a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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