|Application ||WB, E|
|Calculated MW||142647 Da|
|Other Names||G-protein coupled receptor 124, Tumor endothelial marker 5, GPR124, KIAA1531, TEM5|
|Target/Specificity||This GPR124 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1259-1293 amino acids from human GPR124.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR124 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).|
|Cellular Location||Cell membrane; Multi- pass membrane protein. Cell projection, filopodium. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact.|
|Tissue Location||Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).|
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Provided below are standard protocols that you may find useful for product applications.
Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity).
Carson-Walter E.B.,et al.Cancer Res. 61:6649-6655(2001).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
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