|Application ||WB, E|
|Calculated MW||210297 Da|
|Other Names||Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, EMSY interactor protein, GW182 autoantigen, Protein GW1, Glycine-tryptophan protein of 182 kDa, TNRC6A, CAGH26, KIAA1460, TNRC6|
|Target/Specificity||This TNRC6A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 855-885 amino acids from the Central region of human TNRC6A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNRC6A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAGH26, KIAA1460, TNRC6|
|Function||Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes.|
|Cellular Location||Cytoplasm, P-body Note=Mammalian P-bodies are also known as GW bodies (GWBs)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Eystathioy T.,et al.Mol. Biol. Cell 13:1338-1351(2002).
Hughes-Davies L.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Martin J.,et al.Nature 432:988-994(2004).
Margolis R.L.,et al.Hum. Genet. 100:114-122(1997).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.