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NAT8L Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NAT8L Antibody (N-Term) AP21925a
    Anti-NAT8L Antibody (N-Term) at 1:1000 dilution + U-87 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 33 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • IHC-P-Leica - NAT8L Antibody (N-Term) AP21925a
    Immunohistochemical analysis of AP21925A on paraffin-embedded human kidney tissue was performed on the Leica® BOND RXm. Tissue was fixed with formaldehyde at room temperature. Heat induced epitope retrieval was performed by EDTA buffer (pH9. 0). Samples were incubated with primary antibody(1:250) for 15min at room temperature. Leica Bond Polymer Refine Detection was used as the secondary antibody.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P-Leica, WB, E
Primary Accession Q8N9F0
Other Accession Q3UGX3, D3ZVU9
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 32837 Da
Additional Information
Gene ID 339983
Other Names N-acetylaspartate synthetase, NAA synthetase, 2.3.1.17, Camello-like protein 3, N-acetyltransferase 8-like protein, NAT8L, CML3
Target/Specificity This NAT8L antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 59-93 amino acids from human NAT8L.
Dilution WB~~1:1000
IHC-P-Leica~~1:250
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNAT8L Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NAT8L (HGNC:26742)
Synonyms CML3
Function Catalyzes the synthesis of N-acetylaspartate acid (NAA) from L-aspartate and acetyl-CoA (PubMed:19524112, PubMed:19807691, PubMed:20385109). Promotes dopamine uptake by regulating TNF-alpha expression (By similarity). Attenuates methamphetamine-induced inhibition of dopamine uptake (PubMed:20385109).
Cellular Location Cytoplasm. Microsome membrane {ECO:0000250|UniProtKB:D3ZVU9}; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q3UGX3}; Single-pass membrane protein. Note=Its enzymatic activity contribution is quantitatively larger in mitochondrial compartment than in extramitochondrial compartment.
Tissue Location Expressed in brain..
Research Areas
Citations (0)
citation

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Background

Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake.

References

Hillier L.W.,et al.Nature 434:724-731(2005).
Brandenberger R.,et al.Nat. Biotechnol. 22:707-716(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Popsueva A.E.,et al.Dev. Biol. 234:483-496(2001).
Arun P.,et al.Neurochem. Int. 55:219-225(2009).

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$ 365.00
$ 140.00
Cat# AP21925a
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