|Application ||WB, E|
|Calculated MW||180930 Da|
|Other Names||Roundabout homolog 1, Deleted in U twenty twenty, H-Robo-1, ROBO1, DUTT1|
|Target/Specificity||This ROBO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1097-1130 amino acids from human ROBO1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ROBO1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed, with exception of kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development.
Kidd T.,et al.Cell 92:205-215(1998).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Brose K.,et al.Cell 96:795-806(1999).
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