|Application ||WB, E|
|Calculated MW||16083 Da|
|Other Names||Phospholipase A2, membrane associated, 126.96.36.199, GIIC sPLA2, Group IIA phospholipase A2, Non-pancreatic secretory phospholipase A2, NPS-PLA2, Phosphatidylcholine 2-acylhydrolase 2A, PLA2G2A, PLA2B, PLA2L, RASF-A|
|Target/Specificity||This PLA2G2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-62 amino acids from human PLA2G2A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLA2G2A Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PLA2B, PLA2L, RASF-A|
|Function||Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).|
|Cellular Location||Cell membrane; Peripheral membrane protein. Secreted|
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Thought to participate in the regulation of the phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides.
Seilhamer J.J.,et al.J. Biol. Chem. 264:5335-5338(1989).
Kramer R.M.,et al.J. Biol. Chem. 264:5768-5775(1989).
Kramer R.M.,et al.Adv. Exp. Med. Biol. 275:35-53(1990).
Liang N.S.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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