|Application ||WB, E|
|Other Accession||Q5KR49, P04268, P58773, P13104, P09493, P84335, P58771, P42639, P58772, P13105, P04692, Q01173, Q5KR47, A1XQV4|
|Predicted||Bovine, Chicken, Human, Mouse, Pig, Rat|
|Calculated MW||32950 Da|
|Other Names||Tropomyosin alpha-3 chain, Gamma-tropomyosin, Tropomyosin-3, Tropomyosin-5, hTM5, TPM3|
|Target/Specificity||This TPM3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 245-276 amino acids from the human region of human TPM3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPM3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.|
|Cellular Location||Cytoplasm, cytoskeleton.|
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Provided below are standard protocols that you may find useful for product applications.
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Reinach F.C.,et al.Nature 322:648-650(1986).
McLeod A.R.,et al.Nucleic Acids Res. 14:8413-8426(1986).
Clayton L.,et al.J. Mol. Biol. 201:507-515(1988).
Lin J.J.-C.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Gregory S.G.,et al.Nature 441:315-321(2006).
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