|Application ||WB, E|
|Calculated MW||16561 Da|
|Other Names||Thyroid hormone-inducible hepatic protein, Spot 14 protein, S14, SPOT14, THRSP|
|Target/Specificity||This THRSP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-48 amino acids from human THRSP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THRSP Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Mainly expressed in tissues that synthesize triglycerides|
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Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.
Grillasca J.-P.,et al.FEBS Lett. 401:38-42(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Chou W.Y.,et al.Biochem. Biophys. Res. Commun. 357:133-138(2007).
Chou W.Y.,et al.Int. J. Biochem. Cell Biol. 40:1826-1834(2008).
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