PDE2A Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q922S4 |
Other Accession | P14099, Q0106, O00408, Q01062 |
Reactivity | Mouse |
Predicted | Bovine, Human, Rat |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 105619 Da |
Gene ID | 207728 |
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Other Names | cGMP-dependent 3', 5'-cyclic phosphodiesterase, 3.1.4.17, Cyclic GMP-stimulated phosphodiesterase, CGS-PDE, cGSPDE, PDE2A |
Target/Specificity | This PDE2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 780-810 amino acids of mouse PDE2A. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PDE2A Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Pde2a {ECO:0000312|MGI:MGI:2446107} |
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Function | cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:21724846). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity). |
Cellular Location | [Isoform PDE2A1]: Cytoplasm {ECO:0000250|UniProtKB:O00408} [Isoform PDE2A3]: Cell membrane {ECO:0000250|UniProtKB:O00408}; Lipid-anchor {ECO:0000250|UniProtKB:O00408} |
Tissue Location | [Isoform PDE2A2]: Expressed in brain and liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
References
Rosman G.J.,et al.Gene 191:89-95(1997).
Bugaj-Gaweda B.,et al.Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
Russwurm C.,et al.J. Biol. Chem. 284:25782-25790(2009).
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