|Application ||WB, E|
|Other Accession||Q9DBG9, Q4QQV1|
|Calculated MW||13735 Da|
|Other Names||Tax1-binding protein 3, Glutaminase-interacting protein 3, Tax interaction protein 1, TIP-1, Tax-interacting protein 1, TAX1BP3 (HGNC:30684)|
|Target/Specificity||This TAX1BP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 71-103 amino acids from human TAX1BP3.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAX1BP3 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.|
|Cellular Location||Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins|
|Tissue Location||Ubiquitous. Detected in brain, heart, kidney, lung, small intestine and skeletal muscle. Detected in various cell lines including HeLa. Weakly expressed in peripheral blood leukocytes.|
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May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.
Rousset R.,et al.Oncogene 16:643-654(1998).
Touchman J.W.,et al.Genome Res. 10:165-173(2000).
Olalla L.,et al.FEBS Lett. 488:116-122(2001).
Honore B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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