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MTUS1 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9ULD2 |
| Other Accession | Q5R9I1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 141397 Da |
| Gene ID | 57509 |
|---|---|
| Other Names | Microtubule-associated tumor suppressor 1, AT2 receptor-binding protein, Angiotensin-II type 2 receptor-interacting protein, Mitochondrial tumor suppressor 1, MTUS1, ATBP, ATIP, GK1, KIAA1288, MTSG1 |
| Target/Specificity | This MTUS1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 983-1017 amino acids from human MTUS1. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MTUS1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MTUS1 |
|---|---|
| Synonyms | ATBP, ATIP, GK1, KIAA1288, MTSG1 |
| Function | Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. |
| Cellular Location | Mitochondrion. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. |
| Tissue Location | Ubiquitously expressed (at protein level). Highly expressed in brain. Down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma and head and neck squamous cell carcinoma (HNSCC). Isoform 1 is the major isoform in most peripheral tissues Isoform 2 is abundant in most peripheral tissues. Isoform 3 is the major isoform in brain, female reproductive tissues, thyroid and heart Within brain it is highly expressed in corpus callosum and pons Isoform 6 is brain-specific, it is the major isoform in cerebellum and fetal brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth.
References
Kinjo T.,et al.J. Hum. Genet. 45:12-17(2000).
Seibold S.,et al.FASEB J. 17:1180-1182(2003).
Nouet S.,et al.J. Biol. Chem. 279:28989-28997(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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