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ACO1 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - ACO1 Antibody (N-Term) AP22028a
    All lanes : Anti-ACO1 Antibody (N-Term) at 1:2000 dilution Lane 1: U-2OS whole cell lysate Lane 2: mouse kidney lysate Lane 3: rat kidney lysate Lane 4: human kidney lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 98 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P21399
Other Accession Q01059, Q63270
Reactivity Human, Mouse, Rat
Predicted Rabbit
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 98399 Da
Additional Information
Gene ID 48
Other Names Cytoplasmic aconitate hydratase, Aconitase, 4.2.1.3, Citrate hydro-lyase, Ferritin repressor protein, Iron regulatory protein 1, IRP1, Iron-responsive element-binding protein 1, IRE-BP 1, ACO1, IREB1
Target/Specificity This ACO1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 124-155 amino acids from human ACO1.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsACO1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ACO1
Synonyms IREB1
Function Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1946430, PubMed:1281544, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1946430, PubMed:1281544, PubMed:8041788, PubMed:23891004).
Cellular Location Cytoplasm, cytosol.
Research Areas
Citations (0)
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Background

Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.

References

Hirling H.,et al.Nucleic Acids Res. 20:33-39(1992).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Rouault T.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7958-7962(1990).
Hentze M.W.,et al.Nucleic Acids Res. 19:1739-1740(1991).

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$ 365.00
$ 140.00
Cat# AP22028a
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