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MGAT4A Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UM21 |
| Other Accession | Q5F407, Q4R854, Q5REP8 |
| Reactivity | Mouse |
| Predicted | Chicken, Monkey |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61544 Da |
| Antigen Region | 70-102 aa |
| Gene ID | 11320 |
|---|---|
| Other Names | Alpha-1, 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A, 2.4.1.145, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa, GlcNAc-T IVa, GnT-IVa, N-acetylglucosaminyltransferase IVa, UDP-N-acetylglucosamine: alpha-1, 3-D-mannoside beta-1, 4-N-acetylglucosaminyltransferase IVa, Alpha-1, 3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form, MGAT4A |
| Target/Specificity | This MGAT4A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 70-102 amino acids from human MGAT4A. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MGAT4A Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MGAT4A (HGNC:7047) |
|---|---|
| Function | Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity). |
| Cellular Location | [Alpha-1,3-mannosyl-glycoprotein 4-beta-N- acetylglucosaminyltransferase A]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2} |
| Tissue Location | Expressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells.
References
Yoshida A.,et al.Glycobiology 9:303-310(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Minowa M.T.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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