|Application ||WB, E|
|Calculated MW||111401 Da|
|Other Names||Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, 220.127.116.11, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, DPYD|
|Target/Specificity||This DPYD antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 841-875 amino acids from human DPYD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPYD Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.|
|Tissue Location||Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells|
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Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Yokota H.,et al.J. Biol. Chem. 269:23192-23196(1994).
Johnson M.R.,et al.Cancer Res. 57:1660-1663(1997).
Ogura K.,et al.Cancer Lett. 122:107-113(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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