|Application ||WB, E|
|Calculated MW||111401 Da|
|Other Names||Dihydropyrimidine dehydrogenase [NADP(+)], DHPDHase, DPD, 126.96.36.199, Dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, DPYD|
|Target/Specificity||This DPYD antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 841-875 amino acids from human DPYD.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPYD Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.|
|Tissue Location||Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells|
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Provided below are standard protocols that you may find useful for product applications.
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Yokota H.,et al.J. Biol. Chem. 269:23192-23196(1994).
Johnson M.R.,et al.Cancer Res. 57:1660-1663(1997).
Ogura K.,et al.Cancer Lett. 122:107-113(1998).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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