|Application ||IHC-P, E|
|Calculated MW||541370 Da|
|Other Names||Histone-lysine N-methyltransferase 2C, Lysine N-methyltransferase 2C, 126.96.36.199, Homologous to ALR protein, Myeloid/lymphoid or mixed-lineage leukemia protein 3, KMT2C, HALR, KIAA1506, MLL3|
|Target/Specificity||This MLL3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1142-1175 amino acids from the N-terminal region of human MLL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MLL3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HALR, KIAA1506, MLL3|
|Function||Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.|
|Tissue Location||Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver|
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Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder.
Ruault M.,et al.Gene 284:73-81(2002).
Tan Y.C.,et al.Cancer Detect. Prev. 25:454-469(2001).
Hillier L.W.,et al.Nature 424:157-164(2003).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
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