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ZDHHC18 Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ZDHHC18 Antibody (C-Term) AP22103b
    Anti-ZDHHC18 Antibody (C-Term) at 1:1000 dilution + human fetal heart lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 42 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9NUE0
Other Accession Q5Y5T2, Q2TGJ1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 42031 Da
Additional Information
Gene ID 84243
Other Names Palmitoyltransferase ZDHHC18, 2.3.1.225, Zinc finger DHHC domain-containing protein 18, DHHC-18, ZDHHC18
Target/Specificity This ZDHHC18 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 331-361 amino acids from human ZDHHC18.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZDHHC18 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZDHHC18 {ECO:0000303|PubMed:35438208, ECO:0000312|HGNC:HGNC:20712}
Function Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK (PubMed:23034182, PubMed:27481942, PubMed:35438208). Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS (PubMed:35438208). May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling (PubMed:27481942).
Cellular Location Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

Has palmitoyltransferase activity towards HRAS and LCK.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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$ 182.50
$ 70.00
Cat# AP22103b
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