|Application ||WB, E|
|Calculated MW||51391 Da|
|Other Names||Chromosome transmission fidelity protein 8 homolog isoform 2, Decreased expression in renal and prostate cancer protein, CHTF8, DERPC|
|Target/Specificity||This CHTF8 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 344-377 amino acids from human CHTF8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CHTF8 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.|
|Tissue Location||Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.|
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Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sun M.,et al.Mol. Med. 8:655-663(2002).
Green A.R.,et al.Breast Cancer Res. Treat. 113:59-66(2009).
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