|Application ||FC, WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||84152 Da|
|Other Names||Neuroendocrine convertase 1, NEC 1, 22.214.171.124, Prohormone convertase 1, Proprotein convertase 1, PC1, PCSK1, NEC1|
|Target/Specificity||This PCSK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 682-715 amino acids from human PCSK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PCSK1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle. Note=Localized in the secretion granules|
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Provided below are standard protocols that you may find useful for product applications.
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
Creemers J.W.M.,et al.FEBS Lett. 300:82-88(1992).
Seidah N.G.,et al.DNA Cell Biol. 11:283-289(1992).
Ohagi S.,et al.Diabetes 45:897-901(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
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