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TXNRD1 Antibody (C-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TXNRD1 Antibody (C-Term) AP22148b
    All lanes : Anti-TXNRD1 Antibody (C-Term) at 1:2000 dilution Lane 1: Hela whole cell lysate Lane 2: Neuro-2a whole cell lysate Lane 3: NIH/3T3 whole cell lysate Lane 4: PC-3 whole cell lysate Lane 5: human testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 71 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q16881
Other Accession Q9JMH6, Q9MYY8, Q5NVA2, O89049
Reactivity Human, Mouse
Predicted Pig, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 70906 Da
Additional Information
Gene ID 7296
Other Names Thioredoxin reductase 1, cytoplasmic, TR, 1.8.1.9, Gene associated with retinoic and interferon-induced mortality 12 protein, GRIM-12, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-102-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF
Target/Specificity This TXNRD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 516-550 amino acids from human TXNRD1.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTXNRD1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNRD1 (HGNC:12437)
Synonyms GRIM12, KDRF
Function Reduces disulfideprotein thioredoxin (Trx) to its dithiol- containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437).
Cellular Location [Isoform 1]: Cytoplasm [Isoform 5]: Cytoplasm
Tissue Location [Isoform 1]: Expressed predominantly in Leydig cells (at protein level). Also expressed in ovary, spleen, heart, liver, kidney and pancreas and in a number of cancer cell lines
Research Areas
Citations (0)
citation

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Background

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

References

Gasdaska P.Y.,et al.FEBS Lett. 373:5-9(1995).
Koishi R.,et al.J. Biol. Chem. 272:2570-2577(1997).
Hofman E.R.,et al.Mol. Cell. Biol. 18:6493-6504(1998).
Rundloef A.-K.,et al.Free Radic. Biol. Med. 36:641-656(2004).
Schuetze N.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.

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$ 182.50
$ 70.00
Cat# AP22148b
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