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FAM125A Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96EY5 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28783 Da |
| Gene ID | 93343 |
|---|---|
| Other Names | Multivesicular body subunit 12A, CIN85/CD2AP family-binding protein, ESCRT-I complex subunit MVB12A, Protein FAM125A, MVB12A, CFBP, FAM125A |
| Target/Specificity | This FAM125A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 152-186 amino acids from the Central region of human FAM125A. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FAM125A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MVB12A |
|---|---|
| Synonyms | CFBP, FAM125A |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. |
| Cellular Location | Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane; Peripheral membrane protein Note=Colocalizes with F-actin. Some fraction may be nuclear |
| Tissue Location | Ubiquitously expressed except in skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor.
References
Konishi H.,et al.J. Biol. Chem. 281:28919-28931(2006).
Beausoleil S.A.,et al.Nat. Biotechnol. 24:1285-1292(2006).
Morita E.,et al.Cell Host Microbe 2:41-53(2007).
Morita E.,et al.EMBO J. 26:4215-4227(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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