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FERMT3 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8K1B8 |
| Other Accession | Q86UX7, Q32LP0 |
| Reactivity | Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 75635 Da |
| Antigen Region | 117-151 aa |
| Gene ID | 108101 |
|---|---|
| Other Names | Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2, FERMT3, KIND3, MIG2B, URP2 |
| Target/Specificity | This FERMT3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids of mouse FERMT3. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FERMT3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Fermt3 |
|---|---|
| Synonyms | Kind3, Urp2 |
| Function | Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053). |
| Cellular Location | Cell projection, podosome. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells |
| Tissue Location | Specifically expressed in hematopoietic cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).
References
Weinstein E.J.,et al.Biochim. Biophys. Acta 1637:207-216(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Boyd R.S.,et al.Leukemia 17:1605-1612(2003).
Wang L.,et al.Biochem. Biophys. Res. Commun. 368:899-906(2008).
Mory A.,et al.Blood 112:2591-2591(2008).
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