|Application ||WB, E|
|Other Accession||Q921T2, Q5PQX1|
|Calculated MW||66248 Da|
|Other Names||Torsin-1A-interacting protein 1, Lamin-associated protein 1B, LAP1B, TOR1AIP1, LAP1|
|Target/Specificity||This TOR1AIP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 42-76 amino acids from human TOR1AIP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TOR1AIP1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.|
|Cellular Location||Nucleus inner membrane; Single-pass membrane protein|
|Tissue Location||Expressed in muscle, liver and kidney.|
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Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kondo Y.,et al.Biochem. Biophys. Res. Commun. 294:770-778(2002).
Goodchild R.E.,et al.J. Cell Biol. 168:855-862(2005).
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