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TOR1AIP1 Antibody (N-Term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TOR1AIP1 Antibody (N-Term) AP22181a
    Anti-TOR1AIP1 Antibody (N-Term) at 1:2000 dilution + mouse testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 66 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q5JTV8
Other Accession Q921T2, Q5PQX1
Reactivity Mouse
Predicted Human, Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit IgG
Calculated MW 66248 Da
Additional Information
Gene ID 26092
Other Names Torsin-1A-interacting protein 1, Lamin-associated protein 1B, LAP1B, TOR1AIP1, LAP1
Target/Specificity This TOR1AIP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 42-76 amino acids from human TOR1AIP1.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTOR1AIP1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TOR1AIP1
Synonyms LAP1
Function Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.
Cellular Location Nucleus inner membrane; Single-pass membrane protein
Tissue Location Expressed in muscle, liver and kidney. [Isoform 4]: Expressed at higher levels than isoform 1 in lung, kidney and spleen (at protein level). Expressed at lower levels than isoform 1 in liver, brain and heart (at protein level). Similar levels of isoforms 1 and 4 are observed in ovary, testis and pancreas (at protein level).
Research Areas
Citations (0)
citation

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Background

Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Kondo Y.,et al.Biochem. Biophys. Res. Commun. 294:770-778(2002).
Goodchild R.E.,et al.J. Cell Biol. 168:855-862(2005).

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$ 182.50
$ 70.00
Cat# AP22181a
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