PARP10 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q53GL7 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 109998 Da |
Gene ID | 84875 |
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Other Names | Poly [ADP-ribose] polymerase 10, PARP-10, 2.4.2.30, ADP-ribosyltransferase diphtheria toxin-like 10, ARTD10, PARP10 |
Target/Specificity | This PARP10 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 565-597 amino acids from the Central region of human PARP10. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PARP10 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PARP10 (HGNC:25895) |
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Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins (PubMed:18851833, PubMed:23332125, PubMed:23474714, PubMed:25043379). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (PubMed:18851833). Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity (PubMed:23332125). Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA (PubMed:24695737). |
Cellular Location | Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325). A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325) |
Tissue Location | Highly expressed in spleen and thymus (PubMed:15674325). Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes (PubMed:15674325) Low expression in heart, brain, placenta, lung, skeletal muscle, and colon (PubMed:15674325). |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
References
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Yu M.,et al.Oncogene 24:1982-1993(2005).
Chou H.Y.,et al.J. Biol. Chem. 281:15201-15207(2006).
Choudhary C.,et al.Science 325:834-840(2009).
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