|Application ||WB, E|
|Calculated MW||89302 Da|
|Other Names||Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase, 2.1.1.-, Nucleolar protein 1, Nucleolar protein 2 homolog, Proliferating-cell nucleolar antigen p120, Proliferation-associated nucleolar protein p120, NOP2, NOL1, NSUN1|
|Target/Specificity||This NOP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 9-43 amino acids from human NOP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NOP2 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable).|
|Cellular Location||Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation.
Fonagy A.,et al.Cancer Commun. 1:243-251(1989).
Larson R.G.,et al.Cancer Commun. 2:63-71(1990).
Valdez B.C.,et al.Cancer Res. 52:5681-5686(1992).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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