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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GBA2 Antibody (Center)   

GBA2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GBA2 Antibody (Center) AP22212c
    All lanes : Anti-GBA2 Antibody (Center) at 1:2000 dilution Lane 1: human brain lysate Lane 2: mouse brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 105 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9HCG7
Other Accession Q69ZF3, Q5M868
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 104649 Da
Additional Information
Gene ID 57704
Other Names Non-lysosomal glucosylceramidase, NLGase, 3.2.1.45, Beta-glucocerebrosidase 2, Beta-glucosidase 2, Glucosylceramidase 2, GBA2, KIAA1605
Target/Specificity This GBA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 593-623 amino acids from the Central region of human GBA2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGBA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GBA2
Synonyms KIAA1605
Function Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.
Cellular Location Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Not localized to lipid rafts
Tissue Location Widely expressed. Highly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower level in liver.
Research Areas
Citations (0)

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Background

Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation and prevention of glycolipid accumulation. May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such activity is unclear in vivo. Plays a role in central nevous system development. Required for proper formation of motor neuron axons.

References

Matern H.,et al.J. Biol. Chem. 276:37929-37933(2001).
Nagase T.,et al.DNA Res. 7:273-281(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 295.00
$ 99.00
Cat# AP22212c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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