|Application ||WB, E|
|Calculated MW||214721 Da|
|Other Names||A disintegrin and metalloproteinase with thrombospondin motifs 20, ADAM-TS 20, ADAM-TS20, ADAMTS-20, 3.4.24.-, ADAMTS20|
|Target/Specificity||This ADAMTS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 782-816 amino acids from the Central region of human ADAMTS20.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAMTS20 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Very sparingly expressed, although is detected at low levels in testis, prostate, ovary, heart, placenta, lung and pancreas. Overexpressed in several brain, colon and breast carcinomas|
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May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain.
Somerville R.P.,et al.J. Biol. Chem. 278:9503-9513(2003).
Llamazares M.,et al.J. Biol. Chem. 278:13382-13389(2003).
Scherer S.E.,et al.Nature 440:346-351(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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