|Application ||WB, E|
|Other Accession||Q90623, Q6DRG7, Q9DBR7, Q10728|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||115281 Da|
|Other Names||Protein phosphatase 1 regulatory subunit 12A, Myosin phosphatase-targeting subunit 1, Myosin phosphatase target subunit 1, Protein phosphatase myosin-binding subunit, PPP1R12A, MBS, MYPT1|
|Target/Specificity||This MYPT1 (Thr696) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 669-702 amino acids from the human MYPT1.|
|Precautions||MYPT1 (Thr696) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity.|
|Cellular Location||Cytoplasm. Note=Along actomyosin filaments and stress fibers|
|Tissue Location||Expressed in striated muscles, specifically in type 2a fibers (at protein level).|
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Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity.
Takahashi N.,et al.Genomics 44:150-152(1997).
Guo J.H.,et al.Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
Xia D.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
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