PLEC Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF, E |
---|---|
Primary Accession | Q15149 |
Other Accession | Q9JI55, Q9QXS1, P30427 |
Reactivity | Human |
Predicted | Hamster, Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 531791 Da |
Gene ID | 5339 |
---|---|
Other Names | Plectin, PCN, PLTN, Hemidesmosomal protein 1, HD1, Plectin-1, PLEC, PLEC1 |
Target/Specificity | This PLEC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4241-4275 amino acids from human PLEC. |
Dilution | IF~~1:25 WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PLEC Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLEC |
---|---|
Synonyms | PLEC1 |
Function | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. |
Cellular Location | Cytoplasm, cytoskeleton. Cell junction, hemidesmosome |
Tissue Location | Widely expressed with highest levels in muscle, heart, placenta and spinal cord |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofibers integrity.
References
Liu C.-G.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:4278-4283(1996).
McLean W.H.I.,et al.Genes Dev. 10:1724-1735(1996).
Zhang T.,et al.Genome Res. 14:79-89(2004).
Nusbaum C.,et al.Nature 439:331-335(2006).
Bienvenut W.V.,et al.Submitted (DEC-2008) to UniProtKB.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.