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SLC1A3 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P43003 |
| Other Accession | P46411 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59572 Da |
| Gene ID | 6507 |
|---|---|
| Other Names | Excitatory amino acid transporter 1, Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3, SLC1A3, EAAT1, GLAST, GLAST1 |
| Target/Specificity | This SLC1A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 127-161 amino acids from human SLC1A3. |
| Dilution | WB~~1:8000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC1A3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC1A3 (HGNC:10941) |
|---|---|
| Function | Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
References
Shashidharan P.,et al.Biochim. Biophys. Acta 1216:161-164(1993).
Arriza J.L.,et al.J. Neurosci. 14:5559-5569(1994).
Kawakami H.,et al.Biochem. Biophys. Res. Commun. 199:171-176(1994).
Stoffel W.,et al.FEBS Lett. 386:189-193(1996).
Vallejo-Illarramendi A.,et al.J. Neurochem. 95:341-348(2005).
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