|Application ||WB, E|
|Calculated MW||47547 Da|
|Other Names||RGM domain family member B, DRG11-responsive axonal guidance and outgrowth of neurite, DRAGON, RGMB|
|Target/Specificity||This RGMB antibody is generated from a rabbit immunized with a recombinant protein of human RGMB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RGMB Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft|
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Provided below are standard protocols that you may find useful for product applications.
Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Schmutz J.,et al.Nature 431:268-274(2004).
Liu X.,et al.Biochem. Biophys. Res. Commun. 382:795-800(2009).
Bell C.H.,et al.Science 341:77-80(2013).
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