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MYL2 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P-Leica, E |
|---|---|
| Primary Accession | P10916 |
| Other Accession | P02610, P51667, Q7M2V4, P08733 |
| Reactivity | Human, Mouse, Rat |
| Predicted | Chicken, Rabbit |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18789 Da |
| Gene ID | 4633 |
|---|---|
| Other Names | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, MLC-2v, MYL2 |
| Target/Specificity | This MYL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 42-75 amino acids from the Central region of human MYL2. |
| Dilution | WB~~1:2000 IHC-P-Leica~~1:1000 IHC~~1:250 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYL2 (HGNC:7583) |
|---|---|
| Function | Contractile protein that plays a role in heart development and function (PubMed:23365102, PubMed:32453731). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). |
| Cellular Location | Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733} |
| Tissue Location | Highly expressed in type I muscle fibers. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
Libera L.D.,et al.Nucleic Acids Res. 17:2360-2360(1989).
Wu Q.L.,et al.Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
Margossian S.S.,et al.Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
Wadgaonkar R.,et al.Cell. Mol. Biol. Res. 39:13-26(1993).
Kovalyov L.I.,et al.Electrophoresis 16:1160-1169(1995).
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