|Application ||WB, E|
|Calculated MW||74605 Da|
|Other Names||Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4|
|Target/Specificity||This DLL4 antibody is generated from a rabbit immunized with a recombinant protein from the human region of human DLL4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DLL4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in vascular endothelium.|
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Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.
Shutter J.R.,et al.Genes Dev. 14:1313-1318(2000).
Sakano S.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Yoneya T.,et al.J. Biochem. 129:27-34(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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