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NCR3 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14931 |
| Other Accession | P61484 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21593 Da |
| Gene ID | 259197 |
|---|---|
| Other Names | Natural cytotoxicity triggering receptor 3, Activating natural killer receptor p30, Natural killer cell p30-related protein, NK-p30, NKp30, CD337, NCR3, 1C7, LY117 |
| Target/Specificity | This NCR3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 31-65 amino acids from the human region of human NCR3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NCR3 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NCR3 |
|---|---|
| Synonyms | 1C7, LY117 |
| Function | Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
| Tissue Location | Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Cytotoxicity-activating receptor that contributes to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
References
Pende D.,et al.J. Exp. Med. 190:1505-1516(1999).
Sato M.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Neville M.J.,et al.J. Immunol. 162:4745-4754(1999).
Nalabolu S.R.,et al.Genomics 31:215-222(1996).
Xie T.,et al.Genome Res. 13:2621-2636(2003).
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