|Application ||WB, IHC-P, FC, E|
|Other Accession||B0BMW8, P57791, A6H7A0|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||35833 Da|
|Antigen Region||41-71 aa|
|Other Names||CAAX prenyl protease 2, 3422-, Farnesylated proteins-converting enzyme 2, FACE-2, Prenyl protein-specific endoprotease 2, RCE1 homolog, hRCE1, RCE1, FACE2, RCE1A, RCE1B|
|Target/Specificity||This RCE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-71 amino acids from the N-terminal region of human RCE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RCE1 Antibody (N-term W57) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FACE2, RCE1A, RCE1B|
|Function||Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
RCE1 is an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.
Maske, C.P., et al., J. Cell Biol. 162(7):1223-1232 (2003).
Hollander, I.J., et al., Biochim. Biophys. Acta 1649(1):24-29 (2003).
Freije, J.M., et al., Genomics 58(3):270-280 (1999).
Otto, J.C., et al., J. Biol. Chem. 274(13):8379-8382 (1999).
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