|Application ||WB, IHC-P, FC, E|
|Other Accession||B0BMW8, P57791, A6H7A0|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||35833 Da|
|Antigen Region||41-71 aa|
|Other Names||CAAX prenyl protease 2, 3422-, Farnesylated proteins-converting enzyme 2, FACE-2, Prenyl protein-specific endoprotease 2, RCE1 homolog, hRCE1, RCE1, FACE2, RCE1A, RCE1B|
|Target/Specificity||This RCE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-71 amino acids from the N-terminal region of human RCE1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RCE1 Antibody (N-term W57) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FACE2, RCE1A, RCE1B|
|Function||Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (PubMed:10085068).|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
RCE1 is an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins.
Maske, C.P., et al., J. Cell Biol. 162(7):1223-1232 (2003).
Hollander, I.J., et al., Biochim. Biophys. Acta 1649(1):24-29 (2003).
Freije, J.M., et al., Genomics 58(3):270-280 (1999).
Otto, J.C., et al., J. Biol. Chem. 274(13):8379-8382 (1999).
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