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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSF1 Sumoylation Site Antibody   

HSF1 Sumoylation Site Antibody

Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - HSF1 Sumoylation Site Antibody AP2501a
    HSF1 Antibody (Cat. #AP2501a) western blot analysis in Jurkat cell line and mouse heart tissue lysates (35ug/lane).This demonstrates the HSF1 antibody detected the HSF1 protein (arrow).
  • IF - HSF1 Sumoylation Site Antibody AP2501a
    Confocal immunofluorescent analysis of HSF1 Sumoylation Site Antibody (Cat#AP2501a) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00613
Other Accession Q08DJ8
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57260 Da
Antigen Region 278-309 aa
Additional Information
Gene ID 3297
Other Names Heat shock factor protein 1, HSF 1, Heat shock transcription factor 1, HSTF 1, HSF1, HSTF1
Target/Specificity This HSF1 Sumoylation Site antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-309 amino acids from human HSF1 Sumoylation Site.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSF1 Sumoylation Site Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSF1
Synonyms HSTF1
Function DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules
Research Areas
Citations (0)

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Heat shock transcription factor 1 (HSF1) mediates the induction of heat shock protein gene expression in cells exposed to elevated temperature and other stress conditions. In response to stress, HSF1 acquires DNA-binding ability and localizes to nuclear stress granules. SUMO modification of HSF1 converts HSF1 to the DNA-binding form. HSF1 colocalizes with SUMO-1 in nuclear stress granules, which is prevented by mutation of the HSF1 lysine targeted for sumoylation.


Hilgarth, et al., Biochem Biophys Res Commun. 2003 Mar 28;303(1):196-200.
He, H., et al., J. Biol. Chem. 278(37):35465-35475 (2003).
Wang, X., et al., Mol. Cell. Biol. 23(17):6013-6026 (2003).
Ignatenko, N.A., et al., Exp. Cell Res. 288(1):1-8 (2003).
Soncin, F., et al., Biochem. Biophys. Res. Commun. 303(2):700-706 (2003).

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Cat# AP2501a
(40 western blots)
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